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2'3'-cGAMP (sodium salt): Unveiling Systems-Level Control...
2025-10-23
Discover the unique role of 2'3'-cGAMP (sodium salt) in orchestrating STING-mediated innate immune responses at the systems level. This in-depth article explores advanced mechanistic insights and translational strategies, setting a new benchmark for immunotherapy research.
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2'3'-cGAMP (Sodium Salt): Pioneering Precision in STING-M...
2025-10-22
This thought-leadership article delves into the mechanistic and translational significance of 2'3'-cGAMP (sodium salt) as the natural, high-affinity STING agonist. We dissect recent discoveries on endothelial STING-JAK1 interplay, compare the product’s unique capabilities in complex tumor microenvironments, and provide strategic guidance for researchers aiming to harness the full potential of the cGAS-STING pathway in immunotherapy and antiviral interventions.
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Pregnenolone Carbonitrile: Unlocking the Full Translation...
2025-10-21
This thought-leadership article provides translational researchers with an in-depth exploration of Pregnenolone Carbonitrile (PCN), highlighting its mechanistic versatility as both a canonical rodent pregnane X receptor (PXR) agonist and a tool for dissecting hepatic detoxification, liver fibrosis, and water homeostasis. Integrating mechanistic insights from recent studies—including novel data on hypothalamic AVP regulation—this piece offers strategic guidance for harnessing PCN in next-generation preclinical and translational studies. The article positions PCN not only as a gold-standard probe for xenobiotic metabolism but also as a springboard for new research avenues, setting it apart from standard product literature.